The 'Give me all Your Luvin' hitmaker was motivated to make her first album in four years because she was upset with fame and felt like she has something important to say.
She told Sirius XM radio: ''I felt like a caged animal. I felt like I had to scream. I had to get some things off my chest.
''There's something simple and primal and direct about playing guitar and singing.
''I still have a lot to say. I still get p****d off about things. And I still believe in love.''
She also praised producer William Orbit, who worked on 'MDNA' and has previously collaborated with Madonna on her 'Music' and 'Ray of Light' albums.
She added: ''Something magical happens when I work with William. He is a tortured soul, and he brings out the tortured soul in me.''
Madonna - who divorced director Guy Ritchie in 2008 - also claimed she's not as ''in control'' of her career as people perceive her to be.
She said: ''I have great leadership qualities, but I don't think I'll ever be as in control as people believe I am or want me to be.
''The journey is to get close to the answer. The education that you have is your journey. You're learning how to be a human being.''
'MDNA' is released on Friday (23.03.12).